Ebola virus disease (EVD), caused by Ebola viruses, resulted in more than 11 500 deaths according to a recent 2018 WHO report. ... have been identified as a result of this in vitro screening.100 SERMs block Ebola entry by causing a reduction in the accumulation of endolysosomal calcium and the concentration of cellular …
The search for small molecule inhibitors of Ebola virus (EBOV) has led to several high throughput screens over the past 3 years. These have identified a range of FDA-approved active pharmaceutical ingredients (APIs) with anti-EBOV activity and several of which are also active in a mouse in vitro infection model. There are millions of additional …
Filoviruses, such as Ebola virus and Marburg virus, are of significant human health concern. From 2013 to 2016, Ebola virus caused 11,323 fatalities in Western Africa. Since 2018, two Ebola virus disease outbreaks in the Democratic Republic of the Congo resulted in 2354 fatalities.
Filoviruses, such as Ebola virus and Marburg virus, are of significant human health concern. From 2013 to 2016, Ebola virus caused 11,323 fatalities in Western Africa. Since 2018, two Ebola virus disease outbreaks in the Democratic Republic of the Congo resulted in 2354 fatalities. Although there is …
Personal protective equipment for the Ebola virus disease: A comparison of 2 training programs Am J Infect Control. 2015 Dec 1;43(12):1281-7. doi: 10.1016/j.ajic.2015.07.007. Epub 2015 Aug 12. Authors Enrique Casalino 1 ...
The effect of Ebola virus disease (EVD) is fatal and devastating, necessitating several efforts to identify potent biotherapeutic molecules. This review seeks to provide perspectives on complementing existing work on Ebola virus (EBOV) by discussing the role of machine learning (ML) techniques in the prediction of small …
The search for small molecule inhibitors of Ebola virus (EBOV) has led to several high throughput screens over the past 3 years. These have identified a range of FDA-approved active pharmaceutical ...
outbreak of Ebola virus disease. WHO AFRO Sep 2014 • Potential Ebola therapies and vaccines. WHO, 2014. • Use of Convalescent Whole Blood or Plasma Collected from Patients Recovered from Ebola Virus Disease for Transfusion, as an Empirical Treatment during Outbreaks. WHO, 2014. • Guidance on temporary malaria control measures in …
2.2. Ligand preparation and virtual screening. The Mcule database (Kiss et al., 2012), consisting of exactly 35,742,734 compounds as at the time of conducting this work, was used for the virtual screening experiment.The compounds were filtered using the same parameters as earlier reported to ensure that selected compounds have good …
The invention of CRISPR screening technologies has made it possible to untangle complex interactions between the host and viral agents. Moreover, whole-genome and pathway-specific CRISPR screens have facilitated identification of novel drug candidates for treating viral infections. ... Ebola virus (EBOV) CRISPR-ko: GeCKO v2: …
Background: The 2014-2016 Ebola virus (EBOV) outbreak in West Africa highlighted the need for improved therapeutic options against this virus. Approaches targeting host factors/pathways essential for the virus are advantageous because they can potentially target a wide range of viruses, including newly emerging ones and because …
Developed five robust machine learning algorithms to predict Ebola virus cell entry inhibitors. Random forest emerged as the most efficient for predicting anti …
Appropriate screening is essential. ... A Case of Severe Ebola Virus Infection Complicated by Gram-Negative Septicemia. N Engl J Med. 2014 Dec 18;371(25):2394–2401. Lai L, Davey R, Beck A, Xu Y, Suffredini AF, Palmore T wt al. Emergency Postexposure Vaccination With Vesicular Stomatitis Virus-Vectored Ebola Vaccine After Needlestick. …
Ebola Virus Disease (EVD) is one of the most lethal transmissible infections, characterized by a high fatality rate, and caused by a member of the Filoviridae family. The recent large outbreak of EVD in Western Africa (2013–2016) highlighted the worldwide threat represented by the disease and its impact on global public health and …
We assigned to each suspect in the care unit a cost of USD 342 including 1) supportive systematic treatment, 2) personal protective equipment, 3) personnel costs as estimated by Bartsch et al. [ 35 ], and 4) the cost of surveillance estimated at USD 1.8 [ …
A high-throughput screening of 319,855 small molecules from the Molecular Libraries Small Molecule Repository library for their activities against Marburg virus and Ebola virus found two novel macropinocytosis inhibitors that are more potent inhibitors of Ebola virus infection and less toxic than ethylisopropylamiloride. ABSTRACT …
Development of an EBOV MiniG plus system as an advanced tool for anti-Ebola virus drug screening. ... The Ebola virus (EBOV), a member of the genus Ebolavirus and the Filoviridae family, causes a severe disease known as viral hemorrhagic fever in humans and may harm public health worldwide . Once the EBOV virus enters …
Development of Ebola virus disease prediction scores: Screening tools for Ebola suspects at the triage-point during an outbreak PLoS One. 2022 Dec 16;17(12):e0278678. doi: 10.1371/journal.pone.0278678. ... Background: The control of Ebola virus disease (EVD) outbreaks relies on rapid diagnosis and prompt action, a …
Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads. January 2019; ACS Omega 4(1):2353-2361; ... Screening Libraries and for Their Exclusion in Bioassays. J. Med.
Appropriate screening is essential. Early consideration of Ebola disease in the differential diagnosis of a patient with consistent clinical and epidemiological factors …
Since the emergence of the Ebola virus disease, more than 33,000 infections in humans have been recorded with over 40 % death cases (Jacob et al., 2020). The Ebola virus is a single-stranded, negative-sense RNA virus that forms a threadlike shape with an approximate length of about 970 nm and a uniform diameter of 80 nm …
Introduction. In 2014, the outbreak of Ebola virus (EBOV) in West Africa highlighted the direct need for broad-spectrum antiviral drugs for this and other emerging viruses 1,2 and remains currently relevant. EBOV was the causative agent responsible for over 11 310 3 deaths in 10 countries, making it one of the deadliest viral pathogens in …
We have previously described the first Bayesian machine learning models from FDA-approved drug screens, for identifying compounds active against the Ebola virus (EBOV). These models led to the identification of three active molecules in vitro: tilorone, pyronaridine, and quinacrine. A follow-up stud …
Pre-Hospital Screening for Ebola Virus Disease Author: New York State Department of Health Subject: Pre-Hospital Screening for Ebola Virus Disease Keywords: pre-hospital screening, ebola virus disease, pre-hospital, ebola virus disease Created Date: 12/3/2014 1:58:55 PM
Post screening criteria in conspicuous placements at ED triage stations, clinics, and other acute care locations (see suggested screening criteria in Attachment A).
Rapid Visual Screening and Programmable Subtype Classification of Ebola Virus Biomarkers. Mustafa Balcioglu. Department of Chemistry, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY, 12222 USA ... The massive outbreaks of the highly transmissible and lethal Ebola virus disease were caused by …
Background. Ebola virus (EBOV) is a member of Filoviridae virus family, which causes acute hemorrhagic fever with a high case-fatality rate in humans (up to 90%). in a recent outbreak in 2014, it affected Guinea, Liberia, and Sierra Leone, and Nigeria with high case fatality rates [].EBOV is an enveloped, negative-sense RNA virus which …
This Fact Sheet informs you of the significant known and potential risks and benefits of the emergency use of the Centers for Disease Control and Prevention (CDC) Ebola Virus …
In the United States, presumptive testing for Ebola virus (Zaire ebolavirus) is available at 69 Laboratory Response Network (LRN) laboratories located in 49 states using rRT …
Bower H, Grass JE, Veltus E, et al. Delivery of an Ebola Virus-Positive Stillborn Infant in a Rural Community Health Center, Sierra Leone, 2015. Am J Trop Med Hyg 2016;94:417-419. Baggi FM, Taybi A, Kurth A, et al. Management of pregnant women infected with Ebola virus in a treatment centre in Guinea, June 2014. Euro Surveill 2014;19.
